Moisture Monitoring in Fluid Bed Granulation

The Importance of Granulation Moisture

Fluid bed granulation combines active pharmaceutical ingredients (APIs) and excipients into stable granules. The drying phase must be closely monitored. Over-drying creates static electricity and ruins granule integrity; under-drying causes sticky powder clogs and tablet press issues. Moisture must be monitored continuously inside the product bowl.

Fluid Bed Insertion Probes

USTECH designed a custom reflectance probe with a blow-back clean purge nozzle, mounted directly inside the fluid bed granulator bowl. The probe scans the tumbling granules through the fluidization air stream. Real-time moisture content (LOD) is updated every 3 seconds.